Cellular fuel gauge may hold the key to restricting cancer growth

Dec. 27, 2012 ? Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts as a "fuel gauge" in cells; AMPK is turned on when it senses changes in energy levels, and helps to change metabolism when energy levels are low, such as during exercise or when fasting. The researchers found that AMPK also regulates cancer cell metabolism and can restrict cancer cell growth.

The discovery was made by Russell (Rusty) Jones, an assistant professor at McGill's Goodman Cancer Research Centre and the Department of Physiology, Faculty of Medicine. Jones along with his team is the first to show that AMPK can act as a tumour suppressor in animals. The research will be published December 27 in the journal Cell Metabolism.

"Cancer is a disease in which cells lose their normal restraints on growth and start to divide uncontrollably. But, in order for cells to grow quickly they need enough energy to complete the task," Jones explained. "AMPK acts like the fuel gauge in your car -- it lets the body know when energy levels are low, and stops cell growth until there is enough gas in the tank. We wanted to see if this fuel gauge could affect the development and progression of cancer. We found that mice lacking AMPK developed tumours faster, suggesting that AMPK is important for keeping tumour development in check, at least for some types of cancer." For this study, Jones' team focused specifically on a type of blood cancer known as lymphoma. They discovered that the protein Myc, which is activated in more than half of all cancers, could promote lymphoma more rapidly when mice were deficient for AMPK.

One of the ways cancer cells support their enhanced rate of growth is by changing their metabolism, or how they generate energy. Cancer cells are different from normal cells in our body because they preferentially use sugar to fuel their growth. Jones discovered that AMPK plays a specific role in restricting cancer cells' ability to use sugar to fuel their growth. "For cancer cells with low AMPK levels, their metabolism goes into overdrive," explained Prof. Jones. "They use sugar more efficiently, allowing them to grow faster. These results suggest that turning on AMPK in cancer cells may be one way that we can restrict cancer growth."

Jones' breakthrough builds on his previous discovery that the widely prescribed medication metformin, a common diabetes drug, can restrict tumour cell growth. The results bring promise that common therapeutics that turn on AMPK and alter cellular metabolism, such as metformin, may become novel tools for cancer therapy. Jones and his colleagues at McGill are currently exploring clinical applications based on this research.

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The above story is reprinted from materials provided by McGill University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Brandon Faubert, Gino Boily, Said Izreig, Takla Griss, Bozena Samborska, Zhifeng Dong, Fanny Dupuy, Christopher Chambers, Benjamin?J. Fuerth, Benoit Viollet, Orval?A. Mamer, Daina Avizonis, Ralph?J. DeBerardinis, Peter?M. Siegel, Russell?G. Jones. AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In?Vivo. Cell Metabolism, 2012; DOI: 10.1016/j.cmet.2012.12.001

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/S3OtxBo-Q-Q/121227130327.htm

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How Much Money Can You Make With A Manufactured Home ...

An article I wrote recently, telling the story of my first manufactured home community that I purchased for $400,000 and sold around ten years later for $1,525,000, raised the ire of a self-styled industry ?guru? who contended that such amounts cannot be made with a manufactured home community. Of course, a community we closed on a few weeks ago in Kentucky showed an appraised value of over $1,000,000 more than we paid? so it doesn?t seem that unique to us. But it does raise the question of how much money you can realistically expect to make with a manufactured home community.

How much money do you want to make?

People have different goals. Some people are only concerned with trying to get a higher return on their cash, which is currently getting 1% in a CD. Others are trying to create substantial wealth, far beyond a simple return on their down-payment. It?s a free country, so there?s no law on what you have to make from a manufactured home community purchase.

What you make is totally based on what you buy.

If you are buying communities at 7% cap rates which are 100% occupied, with no room for pushing rents or sub-metering utilities, then it is unlikely that you will create much value other than a 10% or so cash-on-cash return. You?ll run the park for a while, maybe make a small rent increase over time, but you?ll probably sell it back for that same 7% cap rate years later, and have a very small amount of profit going to you at closing. On the other hand, if you buy manufactured home communities at a 10% cap rate, and with significant room to push rents, bill-back utilities and fill lots, and then, after successfully putting all those factors into motion, sell that now 18% cap rate purchase for a 9% cap rate, you will have created a huge amount of value, which you will receive as a cashier?s check at closing. That?s one way that you can create $1 million of value with a manufactured home community.

Don?t forget about buying $1 for 50 cents.

Sometimes you can buy a manufactured home community on the front end, that?s already running well, for less than it?s worth. This is normally a result of a seller who has failed to perform proper accounting on his property, including expensing items that should be capitalized, or not collecting the rent because they are too friendly with their tenants.

Benjamin Franklin summed it up.

Benjamin Franklin once said ?diligence is the mother of good luck?. What I think he meant is that your success or failure is based on how you buy the property on the front end. If your goal is to create a significant amount of capital by buying a property that has great numbers going in, with the possibility of even better performance over time, then you can make a lot of money with a manufactured home community. If, however, you buy a community with lousy numbers and no possibility of improvement, then you will make no money? or even lose your money.

But this is not a ?get rich quick scheme?.

Buying and operating manufactured home communities is far from a ?get rich quick scheme?. But that does not mean it?s not a ?get rich scheme?. The only reason to get involved in this industry is to make money? it?s not a sexy business that sounds good at a cocktail party, nor is it really that much fun. But I think it?s safe to say it?s never a ?quick? business. Holding and operating a community for 5 to 10 years is anything but ?quick?.

As the industry becomes more professional, the opportunities will diminish.

Of course, one of the reasons that there is so much money to be made in the manufactured home community business is that the industry is dominated by moms and pops, who are not the most sophisticated sellers. There are roughly 50,000 manufactured home communities in the U.S., and the majority of these are owned by the original founders or folks who have had them for decades. There are hardly any new communities being built, so this supply is static. As professional investors buy out these moms and pops, the profitability of manufactured home communities? based on going-in cap rates and potential income growth will decrease. This means that there is some sense of urgency, and it is not a given that opportunities will always be as ripe as they are now.

There are two types of business models in this industry.

There are public companies that prefer to buy ?finished? goods that are stable but have a lower return, and others who seek out ?turnaround? opportunities that are non-stabilized, and offer higher returns for those who take the time, effort and risk to stabilize them. There is no reason that these two business models cannot happily co-exist. And also no reason that the lower returns of the one niche should apply to the other. The industry ?guru? who believes that it is impossible to make significant money in this business has been hanging around with the guys at the public companies for too long.

Conclusion

I am proud to make significant returns with manufactured home communities. I firmly believe that there is still plenty of opportunity in this industry. Those who think otherwise either don?t really know what they?re talking about, or don?t have what it takes to be a successful community owner.

Source: http://www.reiclub.com/realestateblog/how-much-money-can-you-make-with-a-manufactured-home-community/

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Only balanced plan to avoid "cliff" is Obama's: White House

WASHINGTON (Reuters) - The only proposal that avoids the year-end U.S. "fiscal cliff" in a balanced manner is the one President Barack Obama has put forward, White House spokesman Jay Carney said on Monday.

"The only plan that we have seen that achieves the size and the balance that's required for sustainable - for long-term deficit reduction and for putting our economy on a sustainable fiscal path, is the president's," Carney told reporters at a briefing.

Carney had been asked to comment on reports of a proposal from House of Representatives Speaker John Boehner, a Republican, that would allow top tax rates to rise in exchange for cuts to entitlement programs.

(Reporting By Mark Felsenthal; Editing by Eric Walsh)

Source: http://news.yahoo.com/only-balanced-plan-avoid-cliff-obamas-white-house-185223381--business.html

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Caviar vending machines pop up at L.A. malls

20 hrs.

A. Pawlowski , NBC News contributor

Craving caviar in Los Angeles? There?s a vending machine for that.

Head to three local malls???Westfield Century City, Westfield Topanga and Burbank Town Center ? and you?ll see one of the brand new machines dispensing the prized roe, as well as truffles, escargot and mother-of-pearl spoons.

Prices start at $5, going all the way up to $500, which will get you one ounce of Imperial River Beluga Caviar.

The project is the brainchild of Kelly Stern, who co-owns Beverly Hills Caviar ? a gourmet food supplier located in the tony California community.?

The business plan: Reach customers in wealthy neighborhoods surrounding the malls who may not have convenient access to caviar and expose everyday shoppers to the delicacy, especially younger ones.

?All my friends and family knew about this for a year-and-a-half and no one wanted to tell me that I was crazy, but I could see it in their eyes,? Stern said.

?I did not know what was going to happen when people saw it.?

Stern shopped around the world to find the right kind of vending machine ? it had to keep the caviar cold, have a touch screen, an Internet connection and an attractive display for its gourmet contents. It also had to accept credit cards as well as cash.

She ended up buying parts from seven different countries and putting everything together in Los Angeles. Each machine costs about $85,000???including hardware, software, security and maintenance ? and has about $50,000 worth of inventory inside. The caviar is sold in jars and stays fresh for about a year.

Stern wants to franchise the business to ?every single city in America and the world? when she has more experience with the machines, which she describes as experimental. Stern says no one has ever thought of caviar as a turnkey enterprise, something she wants to change.

?A lot of the people that sell caviar now are old people. They are a dying species and they don?t cater to the young people at all,? Stern said.

?So I?m seeing all the teenagers that stop by as my future assets. They will grow up and become the president of the U.S. or the president of Microsoft and they will think about caviar. They will remember that they went into the mall and saw the machine and that?s where they are going to buy their caviar.?

The project has attracted lots of attention since the machines were unveiled on last week on?Black Friday, prompting Stern to hire a publicist???not to promote the venture, but to manage the curiosity it has sparked.

Industry observers, however, were skeptical whether the business model would be a success.

?It?s interesting, it?s a conversation starter and it?s a marketing tool? (but) I don?t think it?s going to sweep the nation,? said Tim Sanford, editor-in-chief of ?Vending Times,? adding that his staff chuckled when they heard of the concept.

?My guess is that most people who want caviar know how to get it.?

Vending machines often put?much-desired products in high-traffic areas where they can be sold swiftly to people who are there for some other purpose, so the caviar angle sounds more like a way to generate buzz, Sanford said.

But Stern projects she will recoup her money in the next few months, especially with the help of the holidays and awards season in Los Angeles.

?Everybody is talking about it. This is a dream come true,? she said.

Source: http://www.nbcnews.com/business/caviar-vending-machines-pop-l-malls-1C7339203

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Teburu Debuts An Android-Based Online & Mobile Ordering Platform For Restaurants

Teburu, a newly launched tablet-based online and mobile ordering system for restaurants, is now live with a handful of restaurant chains in the Southern U.S, including?Gondolier Pizza, Pita's Republic, and Little Greek?Restaurant, and it has also recently signed a contract with a large, undisclosed Middle Eastern restaurant management company with 600 locations.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/qoYeU9bKCGk/

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